March212014

Anonymous asked: whats the protein in your icon

kem-ist:

thesunalsorises26:

molecularlifesciences:

Ubiquitin!

Hopefully you don’t post too much more ubiquitin…your blog might be labeled for degradation!

Science smackdown.

OMG YES.

12AM
Essential laboratory vocabulary…

Essential laboratory vocabulary…

12AM

Anonymous asked: What evidence is there for (plasma) membrane fluidity?

molecularlifesciences:

Like most ideas in cell biology, the fluid mosaic model of the cell membrane evolved from many previous models as new evidence and techniques came to light.  Initially the bilayer model was proposed by Gorder and Grendel based on membrane from red blood cells and measuring how their area was spread out. Later, freeze-fracturing the cells and using electron microscopy brought a new generation of models.

Science publishedthe model in question 18 February 1972.

The Fluid Mosaic Model of the Structure of Cell Membranes by Singer and Nicolson

In this model, the proteins that are integral to the membrane are a heterogeneous set of globular molecules, each arranged in an amphipathic structure, that is, with the ionic and highly polar groups protruding from the membrane into the aqueous phase, and the nonpolar groups largely buried in the hydrophobic interior of the membrane. These globular molecules are partially embedded in a matrix of phospholipid. The bulk of the phospholipid is organized as a discontinuous, fluid bilayer, although a small fraction of the lipid may interact specifically with the membrane proteins. The fluid mosaic structure is therefore formally analogous to a two-dimensional oriented solution of integral proteins (or lipoproteins) in the viscous phospholipid bilayer solvent.”

The researches use a variety of evidence to support their argument including isotope labeling and antibody labeling.  Modern experiments can  demonstrate this phenomenon using GFP and photobleaching (ref).

March122014
brains-and-bodies:

that-science-bitch:

The development of the human brain
First the embryonic spinal chord is formed along common sequences and patterns then the nervous system develops from a simple elongated neural tubes. The cranial region then differentiates into several clusters of cells which produce the forebrain, midbrain and hindbrain portions.

Nothing gets me hot and bothered like a high encephalization index

brains-and-bodies:

that-science-bitch:

The development of the human brain

First the embryonic spinal chord is formed along common sequences and patterns then the nervous system develops from a simple elongated neural tubes. The cranial region then differentiates into several clusters of cells which produce the forebrain, midbrain and hindbrain portions.

Nothing gets me hot and bothered like a high encephalization index

March112014
Dude, we’re already in the G2 phase!!!

Dude, we’re already in the G2 phase!!!

March102014

She may not be a scientist, but this is some great advice for our women in STEM!

(Source: adoringbeyonce, via mistress-of-science)

March92014

Reblog if it’s okay to invade your ask box.

Feel free to ask me molecular biology related questions - any from career choices to protocols to topics you might be struggling with. I’ll try my best to help :)

(via shychemist)

11PM
March72014
When you feel as though you have single-handedly destroyed the environment after a long day of pipetting.

When you feel as though you have single-handedly destroyed the environment after a long day of pipetting.

(Source: asapscience, via shychemist)

March62014
When you’ve given up on your love life to become a vestile virgin for science

When you’ve given up on your love life to become a vestile virgin for science

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